Position Summary:

TScan is seeking a highly motivated and detail-oriented Clinical Scientist with deep expertise in clinical data management and data review to support the execution of our oncology cell therapy clinical programs. This unique role sits at the intersection of Clinical Development, Clinical Operations, Data Management, and Biostatistics serving as a critical driver of data quality, data integrity, and clinical insight generation.

The Clinical Scientist will be responsible for leading ongoing clinical data review activities, developing data review strategies, identifying and resolving data issues, and ensuring high-quality clinical datasets are available to support safety reviews, regulatory submissions, and clinical decision-making. The successful candidate will possess a strong scientific background combined with hands-on experience in clinical data management, EDC systems, data visualization tools, and cross-functional collaboration.

This position offers an opportunity to play a highly visible role in advancing innovative TCR-T therapies through clinical development while helping establish best-in-class data review and clinical science processes.

Key Responsibilities

Clinical Data Review & Oversight

• Serve as the clinical lead for ongoing data review activities across TScan clinical studies.
• Develop and execute comprehensive data review plans to ensure timely identification and resolution of data discrepancies, trends, and potential safety signals.
• Review patient-level clinical data to assess completeness, consistency, protocol compliance, and medical relevance.
• Partner with Clinical Operations, Data Management, Medical, Pharmacovigilance, and Biostatistics to drive data quality and readiness.
• Lead cross-functional data review meetings and track resolution of key data issues.

Clinical Science & Data Interpretation

• Analyze and interpret emerging clinical, safety, efficacy, and biomarker data to support study conduct and decision-making.
• Support data cleaning efforts for interim analyses, data monitoring committee reviews, and regulatory submissions.
• Contribute to clinical narratives, safety analyses, data listings review, and study reports.
• Collaborate with translational and biomarker teams to integrate clinical and correlative data insights.

Data Management Collaboration

• Partner closely with Data Management to review CRFs, edit checks, data validation plans, and data review specifications.
• Provide clinical input into database design, study builds, and data collection strategies.
• Support UAT testing of EDC systems and associated clinical technologies.
• Review data transfer specifications and external vendor data integration processes.
• Ensure data review activities align with CDISC standards and regulatory expectations.

Clinical Development Support

• Contribute to protocol development, endpoint definitions, and data collection strategies.
• Participate in study team meetings and provide clinical science expertise throughout study execution.
• Support preparation of clinical study reports (CSRs), regulatory documents, investigator brochures, and publications.
• Assist with inspection and audit readiness activities.

Process Improvement & Innovation

• Develop and implement innovative approaches for ongoing clinical data surveillance and risk-based data review.
• Leverage data visualization tools and analytics platforms to enhance clinical data review efficiency.
• Contribute to the development of clinical data review SOPs, work instructions, and best practices.
• Help establish scalable processes to support growth of TScan's clinical portfolio.

Qualifications

Education

• Advanced degree (PharmD, PhD, MS, MPH, or equivalent) in a life sciences, clinical research, or related field preferred.
• Bachelor's degree with significant relevant experience may be considered.

Experience

• 5–8+ years of experience in clinical development, clinical science, data management, or related functions within biotechnology, pharmaceutical, or CRO environments.
• Demonstrated experience performing ongoing clinical data review in oncology or advanced therapy clinical trials.
• Experience working closely with Data Management and Biostatistics teams.
• Experience supporting early- and/or late-stage clinical trials.
• Oncology, immuno-oncology, cell therapy, CAR-T, TCR-T, or hematology experience strongly preferred.

Technical Skills

• Strong understanding of clinical trial conduct, GCP, ICH guidelines, and regulatory requirements.
• Hands-on experience with EDC systems (e.g., Medidata Rave, Veeva EDC, Oracle Inform).
• Experience using clinical data review and visualization tools such as Spotfire, Tableau, JReview, SAS, or similar platforms.
• Familiarity with CDISC standards (SDTM, ADaM) and clinical database structures.
• Strong analytical and problem-solving skills with the ability to interpret complex clinical datasets.
• Understanding of external data sources, including laboratory, imaging, biomarker, and pharmacokinetic data.

Leadership & Collaboration Competencies

• Strong scientific curiosity and attention to detail.
• Ability to synthesize complex clinical data into actionable insights.
• Excellent communication and presentation skills.
• Proven ability to work effectively in highly cross-functional teams.
• Comfortable operating in a fast-paced, evolving biotechnology environment.
• Strong organizational skills with the ability to manage multiple priorities simultaneously.

About TScan:

TScan Therapeutics is a fully integrated, next-generation TCR-T cell therapy company. Founded in 2018, TScan’s platform was developed by Stephen Elledge, Ph.D., and Tomasz Kula, Ph.D., at Brigham and Women’s Hospital and Harvard Medical School. TScan’s transformative platform enables rapid discovery of TCRs and targets for engineered T cell therapy. This technology is extremely versatile and is applicable across multiple therapeutic areas beyond cancers, including autoimmune disorders and infectious diseases.

Do YOU have the anatomy of a TScanner?

Our talented, compassionate, and intelligent team is what makes TScan a Top Place to Work (as ranked by The Boston Globe). Our state-of-the-art offices with over 70,000 square feet of premium lab space, including an internal GMP manufacturing suite, are an environment that supports innovation, camaraderie, and professionalism. We are passionate, fun, flexible, and team oriented. Sound like you? Apply today.

EEO Statement

TScan is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate. TScan provides reasonable accommodations to qualified applicants and employees with disabilities. To begin an interactive dialogue with TScan regarding a reasonable accommodation in connection with the hiring process and/or to perform the responsibilities of the position for which the applicant has applied, please contact the recruiter.

Pay Range: $145,000-$155,000

Pay Transparency

TScan Therapeutics’ pay ranges are established based on external market data from third-party compensation surveys and our internal benchmarking. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Individual compensation within this range is commensurate with a candidate’s specific qualifications, including education, overall experience, relevant experience, and specific skills. We strive to ensure that compensation is competitive, equitable, and aligned with the value each TScanner brings to the role.

Recruitment & Staffing Agencies

TScan Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to TScan Therapeutics or its employees is strictly prohibited unless contacted directly by TScan Therapeutics’ internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of TScan Therapeutics, and TScan Therapeutics will not owe any referral or other fees with respect thereto.